Extensive surgery and radiotherapy of malignant neoplasms in the head and neck region contribute to the formation of prosthetic base defects that are difficult to reconstruct. Frequent complications after oncological treatment lead to deterioration of the patients’ life comfort. Removable dentures routinely used in prosthetic treatment do not meet the expectations of patients due to their poor retention, They are also responsible for injuries to the oral mucosa damaged by radiotherapy. This article describes three cases of prosthetic rehabilitation with the use of intraosseous implants in the mandible. After tumour resection and irradiation of the oral cavity each patient had two implants placed in the anterior segment of the mandible. Dental implants were used to improve the retention of removable prostheses. The applied treatment enabled patients to introduce varied diet and positively influenced their self-esteem. Radiotherapy is not an contraindication for implant placement that is often the only therapeutic possibility for the patients who complain of inadequate retention of their complete dentures. Appropriate precautions allow to avoid inflammatory complications around dental implants.