The prospect of long-term survival and proper, predictable functioning in the oral cavity of permanent restorations made of glass ceramics determines its wide application in dental prosthetics. The implementation of computer technology for the design and manufacturing of permanent prosthetic structures (CAD / CAM) into clinical practice, as well as the dynamic development of dental materials science, enable the processing of ceramic materials with high mechanical strength parameters, and also a very good aesthetic effect. The numerous advantages of glass ceramics reinforced with lithium disilicate or leucite crystals, among which the most frequently mentioned are biocompatibility, translucency, color and shape stability, surface smoothness, the possibility of adhesive cementation and optimal resistance to brittle cracking and bending, make it often the material of first choice in planning prosthetic treatment with the use of prosthetic reconstructions, such as: all-ceramic crowns, veneers, bridges, inlays and hybrid crowns on implants. The aim of this study is to present the indications and possibilities of using permanent restorations made of leucite glass ceramics and lithium disilicate in the reconstruction of quality defects of teeth, as well as in the reconstruction of the continuity of the dental arch in case of quantitative deficiencies, based on the descriptions of the clinical cases of prosthetic treatment with the use of this type of restorations.