Surgical resection is the primary treatment for patients with head and neck neoplasms. Tissue defects resulting from the procedure cause disturbances in function and aesthetics. In addition, numerous changes in the stomatognathic system may occur in this group of patients, making prosthetic rehabilitation difficult. Methods of simplifying production technology and increasing the precision of prosthetic works are constantly sought. The dynamically developing CAD/CAM technologies are also increasingly used in the treatment of post-operative patients. The use of computer-aided design and manufacturing allows for the creation of precise restorations, shortening the rehabilitation time, archiving data and improves communication between different departments. The ability to obtain data from magnetic resonance images (MRI), computed tomography (CT), 3D photogrammetry and intraoral scanning (IS) allows for accurate planning of resection procedures and designing prosthetic restorations that the patient can use from the first days after surgery to restore function, aesthetics and comfort of life. The development of CAD/CAM techniques and materials allows to produce not only standard prosthetic works, but also atypical restorations. Modern digital systems make it possible to simplify often complicated traditional production technologies and are promising in terms of prosthetic rehabilitation with these challenging patients.