The aim of the study is to present the laboratory process of production of complete dentures using modern CAD/CAM technologies. The article presents digital systems for making complete dentures based on CAD/CAM technology and CNC milling, for example AvaDent and Baltic Denture System. The process of laboratory manufacture of 3D printed dentures based on the Dentca system has been described. The advantages and disadvantages of materials used to produce these restorations have also been presented. Prostheses made with CAD/CAM technology require the use of expensive equipment. Computer systems allow shortening the time needed to make dentures and simplify their technical implementation. They enable the restoration of damaged dentures without the patient’s participation. Milled restorations better fit the prosthetic base and have higher retention than the conventional ones, while the printed ones are less accurate. The materials used to make milled dentures have better physical properties than hot polymerized acrylic, but teeth made with this technique are less aesthetic than the ready-made teeth used in the traditional technique. The physical properties of the resins currently used for 3D printing are not suitable for making long-term prostheses. The development of this technology is dynamic, but so far there have been few clinical, long-term monitoring of these restorations.