Fabrication of removable complete dentures is still the most frequently chosen treatment option for edentulous patients. Today, there are modern alternatives to the traditional protocol for performing such prosthetic work. The aim of this study was to present the clinical protocol of fabrication of dentures using modern digital CAD/CAM technology and to describe three prosthetic systems based on this technology – AvaDent, Baltic Denture System and Dentca. Advantages and disadvantages of using individual CAD/CAM systems in the production of complete dentures have been discussed. The use of digital technology offers better physical properties of restorations, eliminating human errors from the technological process. At the same time, it shortens the time needed to submit the finished prosthesis and limits the number of visits and corrections. Conversely, with virtual scans we are not able to reproduce moving soft tissues as accurately as traditional functional impressions do. Moreover, the elimination of a clinical visit to try in the prostheses makes it impossible to eliminate errors arising during the design stage. The above arguments indicate that the use of hybrid methods currently seems to be necessary to make a good complete denture using CAD/ CAM technology.