Loss of mid-facial structures secondary to tumor extirpation occurs a number of anatomical and functional disorders of the prosthetic area. In the prosthetic rehabilitation of this group of patients, achieving satisfactory retention and stabilization of postoperative prosthetic restorations, especially complete dentures with obturators, is a determinant of therapeutic success. In many cases, implant treatment may become the procedures of choice, enabling the support of prosthetic restorations on intraosseous implants. However, common today implant-prosthetic treatment for postoperative patients encounters a number of limitations. In addition to changes in the topography of the prosthetic area, complementary treatments (radio and/or chemotherapy) also have a negative impact on oral tissues. Widely used, especially in edentulous patients, overdentures supported on intraosseous implants can be used successfully in the group of postoperative patients. Particularly useful in this type of prosthetic restorations are retention elements Locator® installed on intraosseous implants. Unfortunately, these standard retainers are only applicable to normal diameter intraosseous implants. Patients in whom it was not possible to insert standard diameter implants were therefore eliminated from this type of prosthetic therapy. This article describes the implant-prosthetic rehabilitation of a patient after resection of the edentulous maxilla and radiotherapy using an implant system dedicated to overdentures in case of a small amount of bone tissue. This allowed satisfactory therapeutic results to be achieved.