The article presents a clinical case of implantoprosthetic rehabilitation of a patient operated on at the age of 14 years due to myxoma located in the area of the left angle of the lower jaw. The surgical treatment included removal of the tumour with partial resection of the mandibular body and branches, and simultaneous reconstruction of the postoperative defect with an autogenous iliac crest graft. Due to the patient’s malocclusion, orthodontic treatment was initiated as a pre-prosthetic preparation. After removal of the braces, a removable lower denture with a metal framework was made to replace missing teeth and provide orthodontic retention. It was planned to replace the prosthesis with a fixed prosthetic restoration supported on intraosseous implants after the end of bone growth. Due to the significant resorption of the integrated bone graft an additional reconstructive procedure was planned to improve the bone quality for future implants. The patient, however, discontinued the treatment and it was six years later that it was resumed. Following another in-depth radiological diagnosis and orthodonto-surgico-prosthetic consultations, a decision was made to implement implantoprosthetic treatment. Three Global D intraosseous implants were inserted in the reconstructed area. After the osseointegration process was completed, a fixed bridge was prepared. The adaptation to the prosthetic restoration was very smooth. In the opinion of the patient, chewing performance significantly improved compared to the situation when the patient had been wearing a conventional prosthesis.