Cleft lip and palate (CLP) represents the most common congenital craniofacial defect, the aetiology of which remains obscure. A key aspect is intervention in the first moments of life, and comprehensive treatment requires the cooperation of specialists. The choice of therapeutic strategy depends on the size of the lip and palate defect, and the quantity and quality of the remaining teeth. The aim of this study was to present the functional and aesthetic rehabilitation of a patient with a complete cleft of the hard and soft palate, with residual dentition in the maxilla and edentulous mandible. The main goal of prosthetic treatment was to restore basic physiological functions such as chewing, swallowing, clear speech, free breathing, and the natural appearance of the face. The clinical process consisted of several stages. The aim of the first stage was to create a prosthesis that limited the obturation opening of the hard and soft palate. In subsequent stages, satisfactory sealing of the prosthesis was achieved through the individualized shaping of the obturating part of the prosthesis. The satisfactory outcome of the treatment had a direct impact on improving the patient’s quality of life.