Surgical treatment of midface tumors leads to tissue loss and impairment of functions such as chewing, speech, breathing, and swallowing. During prosthetic rehabilitation of patients after maxillary resection, prosthetic restorations with an obturator are made to restore lost functions and improve aesthetics. Insufficient denture retention is often observed in the case of edentulous patients, preventing the use of fabricated restorations. Conventional methods of fabricating restorations involve time-consuming clinical and laboratory procedures that are prone to human error. There is a constant search for methods of making prostheses that would simplify the complicated manufacturing techniques developed so far and provide a satisfactory aesthetic and functional effect. Dynamically developing digital technologies allow their increasing use also for prosthetic rehabilitation of postoperative patients. The paper presents a case report of an edentulous patient after the left maxilla resection due to cancer, in whom, based on an intraoral scan, an upper denture plate with a hollow closed obturator was made using 3D printing technology, and the recesses of the post-resection defect were additionally used to increase the retention of the restoration on the substrate.