Materials used in dental prosthetics today must meet the ever-increasing requirements of aesthetics and durability. Due to its mechanical and optical properties, zirconium oxide has a special place in the area of fixed prostheses. It is used both in implant prosthetics and in conventional, fixed prosthetic restorations supported on abutment teeth. Initially, it was used mainly for the manufacture of suprastructures for fixed dentures. Currently, new generations of zirconium oxide materials with increased translucency, which can be used to make monolithic prosthetic replacements, are becoming more popular. Thanks to CAD-CAM technology, full-contour restorations made of zirconium oxide are characterized by high flexural strength and the preparation of abutment teeth is even more conservative. They also minimize wear of the antagonistic teeth, and the whole process is less time consuming both clinically and in the laboratory. As monolithic restorations, they are free from undesirable complications associated with ceramic facing chipping. Despite their advantages, they are not ideal materials devoid of disadvantages. However, the knowledge of the properties of the available materials will facilitate the right choice in specific clinical cases.