Immediate provision of prosthetic restoration to the patient after resection of the palate tissues is intended to restore lost functions as quickly as possible and accelerate the wound healing process by protecting the surgical site. The development of CAD/CAM technologies allows for precise planning, design, and production of prosthetic restorations also for postoperative patients. Additionally, virtually created projects are archived and can be reused or modified depending on clinical needs. The study presents the design of an immediate palatal obturator in the Blue Sky Plan 4 software (Blue Sky Bio, USA) based on an intraoral scan (Trios 3, 3Shape, Denmark) and computed tomography image, as well as fabrication using 3D printing technology in an Asiga Max UV 385 printer (Asiga, Australia) from NextDent Denture 3D+ material (NextDent, the Netherlands). The virtual design of the obturation plate was modified 2 weeks after the procedure according to the changes occurring in the prosthetic substrate as a result of the postresection wound healing.