Quantitative reconstruction of missing teeth with the use of acrylic complete dentures is one of the most common forms of rehabilitation reimbursed under the National Health Fund. Proper hygiene of prosthetic restorations is important for the proper functioning of the stomatognathic system, as well as for the health of the entire oral cavity. In order to assess the hygiene of acrylic dentures, indicators determining the amount of bacterial plaque on their surface are used. Indicators constitute objective diagnostic tools used in the clinical assessment of hygiene status of removable dentures, and can also be helpful in motivating patients to observe the hygiene procedures of dentures. Maintaining proper hygiene minimizes the risk of oral inflammatory conditions. Every patient undergoing prosthetic rehabilitation with the use of acrylic removable dentures should be given detailed instructions on the hygiene of the restorations, including methods of their implementation and accessories necessary for this purpose. The patient should also be advised to carry out hygienization procedures at least twice a day and to report for follow-up visits at least once a year. During follow-up visits, the condition of the mucoosteal area, the fit of the denture, and dynamic and static occlusion should be assessed. Attention should also be paid to the assessment of the denture plaque using known and repeatable indicators for its assessment, which provide reliable information about the state of hygiene of the denture and the amount of bacterial plaque accumulated on the surfaces of the restorations.