Surgical treatment of midface tumours may lead to tissue loss and, in consequence, to functional and aesthetic disorders. Providing the patient with a palatal obturator immediately after the resection procedure reduces the scope of reconstructive surgery, accelerates the wound healing process and allows physicians to restore functions such as chewing, swallowing, breathing and speech. The development of digital technologies enables their wider use in the prosthetic rehabilitation of patients, increasing the accuracy of the fabricated restorations and shortening the rehabilitation time; data archiving is possible, as well as efficient communication between various medical facilities. CAD/CAM technologies are also used in patients treated for head and neck neoplasms. The article presents a clinical case of a patient after tissue resection within the hard and soft palate with subsequent prosthetic rehabilitation with an immediate palatal obturator digitally designed in the Blue Sky Plan 4 program (Blue Sky Bio, USA) based on an intra-oral scan (Trios 3, 3Shape, Denmark) and image of computed tomography performed during the diagnosis of a neoplastic lesion. The prosthetic restoration was made in 3D-printing technology in the Asiga Max UV 385 printer (Asiga, Australia) from the of NextDent Denture 3D+ material (NextDent, the Netherlands).