Despite the rapid development of implants in dentistry, prosthetic rehabilitation of edentulous patients with acrylic dentures, including full dentures, remains a common and frequently chosen method of treatment. Therefore, it is important for every dentist to acquire the skills to utilize correct, functional and aesthetic prosthetic restorations taking into account the position of the mandible in the central relation. The aim of the article is to present the method of making full acrylic dentures using the Centrofix system (Amann Girrbach). Making prostheses according to this system requires at least four clinical visits, during which a double-jaw impression tray is used. Functional impressions are taken on individual trays with the mouth open, intraoral registration of the centric occlusion by means of gothic arch determinationis performed as well as registration of the jaw relation to arbitrary axis of rotation of the temporomandibular joint using a face-bow. Anatomically shaped acrylic teeth are positioned and ready dentures are placed on duplicate models mounted to the articulator. This method requires the prosthetist to use specialized equipment including a Centric Tray (Ivoclar Vivadent), double jaw tray, Centrofix system (Amann Girrbach) as well as the face bow and Artex CPN articulator (Amann Girrbach). The article describes clinical and laboratory stages of the fabrication of biofunctional complete dentures. The benefits and drawbacks of this system have also been presented.